gene copy numbers การใช้

• A study was conducted on ancestral diet and the evolution of the human amylase gene copy number.
• It is also true, however, that some reports have stated that IHC provides excellent correlation between gene copy number and protein expression.
• However, for reasons related to gene copy number effects, possession of extra copies of certain genes is also deleterious to the daughter cells.
• More specifically, for each gene family, PICRUSt maps known gene copy numbers ( from complete sequenced genomes ) onto a reference tree of life.
• Following variations among cells, dPCR enables an increased detection of differences in gene copy number in order to analyze complex behavioral traits, phenotypic variability, and diseases.
• As a tool for clinical geneticists, cytogeneticists and molecular biologists, DECIPHER is used to determine whether gene copy number variations identified in patients are of clinical significance.
• The multiple copies of the AMY1 gene gives those who rely more heavily on high starch diets an evolutionary advantage, therefore the high gene copy number persists in the population.
• His most recent work, first published in the 2005 issue of Science, involves the ethnic group-specific role of CCR5 haplotype and CCL3L1 gene copy number on the progression of HIV to AIDS.
• When applying PICRUSt to a 16S rRNA gene library, PICRUSt matches reference operational taxonomic units against the tables, and retrieves a predicted 16S rRNA copy number and gene copy number for each gene family.
• In Eukarya, AGC isoacceptors are extremely enriched in gene copy number in comparison to the rest of isoacceptors, and this has been correlated with its A-to-I modification of its wobble base.
• Moreover, it permits the detection of chromosomal abnormalities and gene copy number variations ( CNVs ) within and between cells, and further facilitates the detection of uncommon mutations that result in single nucleotide polymorphisms ( SNPs ).
• The recent origin of the multi-copy AMY1 gene implies that depending on the environment, the AMY1 gene copy number can increase and decrease very rapidly relative to genes that do not interact as directly with the environment.
• Notably, while this functionality is typically used for prediction of gene copy numbers in bacteria, it could, in principle, be used for prediction of any other continuous trait given trait data for diverse organisms and a reference phylogeny.
• They found that there was more amylase protein expression in saliva from people that had higher amylase copy number in their genome and there was also an association between groups of people with high starch diets and a larger amylase gene copy number.
• Liu " et al . " cite other possible factors that may distort results, including  differences in gene copy number between species and biases introduced during cell lysis, DNA extraction, and PCR amplification ( p . 4521 ).
• A recent study reported the introduction of two extra copies of just a single gene present in the 15q11.2-q13.1 region, Ube3a, into mice to model the gene copy number expressed in the brain in idic ( 15 ).
• Evolution of the tRNA gene copy number across different species has been linked to the appearance of specific tRNA modification enzymes ( uridine methyltransferases in Bacteria, and adenosine deaminases in Eukarya ), which increase the decoding capacity of a given tRNA . As an example, tRNAAla encodes four different tRNA isoacceptors ( AGC, UGC, GGC and CGC ).
• In one species, " Glycine dolichocarpa " ( a close relative of the soybean, " Glycine max " ), it has been observed that following a genome duplication roughly 500, 000 years ago, there has been a 1.4 fold increase in transcription, indicating that there has been a proportional decrease in transcription relative to gene copy number following the duplication event.